Several treatments more effective in distinctive signatures: (Hormone therapies, TP53-); (Taxel therapies, TEfus+); (Niraparib, DRD+)
By subgroup:
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| — | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.029, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 31.9, median = 26.1 | mean = 31.9, median = 26.1 | |
| effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.82, hr = 1.3 | af = 0.82, hr = 1.3 | |
| –+ | param | scale = 0.024, shape = 1.3 | scale = 0.014, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.029, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 66.5, median = 54.4 | mean = 70.5, median = 57.5 | mean = 31.9, median = 26.1 | |
| effect | af = 1, hr = 1 | af = 1.7, hr = 0.5 | af = 1.8, hr = 0.46 | af = 0.82, hr = 1.3 | |
| -+- | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.029, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 31.9, median = 26.1 | mean = 31.9, median = 26.1 | |
| effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.82, hr = 1.3 | af = 0.82, hr = 1.3 | |
| -++ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 0.82, hr = 1.3 | |
| +– | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 31.9, median = 26.1 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.82, hr = 1.3 | af = 1.9, hr = 0.43 | |
| +-+ | param | scale = 0.024, shape = 1.3 | scale = 0.014, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 66.5, median = 54.4 | mean = 70.5, median = 57.5 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 1.7, hr = 0.5 | af = 1.8, hr = 0.46 | af = 1.9, hr = 0.43 | |
| ++- | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 31.9, median = 26.1 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.82, hr = 1.3 | af = 1.9, hr = 0.43 | |
| +++ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 39, median = 31.9 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.9, hr = 0.43 |
By signature:
| signature | var | Other | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| all | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.021, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 38.3, median = 31.3 | mean = 38.6, median = 31.5 | mean = 43.6, median = 35.6 | |
| effect | af = 1, hr = 1 | af = 0.98, hr = 1.03 | af = 0.99, hr = 1.02 | af = 1.12, hr = 0.87 | |
| TP53- | param | scale = 0.024, shape = 1.3 | scale = 0.022, shape = 1.3 | scale = 0.021, shape = 1.3 | scale = 0.021, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 42.3, median = 34.6 | mean = 43, median = 35.1 | mean = 43.6, median = 35.6 | |
| effect | af = 1, hr = 1 | af = 1.08, hr = 0.9 | af = 1.1, hr = 0.88 | af = 1.12, hr = 0.87 | |
| TP53+ | param | scale = 0.024, shape = 1.3 | scale = 0.026, shape = 1.3 | scale = 0.026, shape = 1.3 | scale = 0.021, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 35.1, median = 28.6 | mean = 35.1, median = 28.6 | mean = 43.6, median = 35.6 | |
| effect | af = 1, hr = 1 | af = 0.9, hr = 1.15 | af = 0.9, hr = 1.15 | af = 1.12, hr = 0.87 | |
| DRD+ | param | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 38.3, median = 31.3 | mean = 38.6, median = 31.5 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 0.98, hr = 1.03 | af = 0.99, hr = 1.02 | af = 1.9, hr = 0.43 | |
| TEfus+ | param | scale = 0.024, shape = 1.3 | scale = 0.019, shape = 1.3 | scale = 0.019, shape = 1.3 | scale = 0.021, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 48.7, median = 39.8 | mean = 49.6, median = 40.5 | mean = 43.6, median = 35.6 | |
| effect | af = 1, hr = 1 | af = 1.25, hr = 0.75 | af = 1.27, hr = 0.73 | af = 1.12, hr = 0.87 |
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The overall error was 0.182.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Niraparib
0.070 0.090 0.038
The overall power was 0.734.
The corresponding power separate for the different treatments were:
Hormone_therapies Taxel_therapies Niraparib
0.056 0.066 0.700
| signature | var | Control | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|
| all | graduation | 0 | 5 | 14 | 10 |
| futility | 0 | 33 | 2 | 39 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 737 (681, 782) | 329 (185, 480) | 355 (218, 496) | 329 (175, 489) | |
| n_unique | 737 (681, 782) | 329 (185, 480) | 355 (218, 496) | 329 (175, 489) | |
| time_trial | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | |
| time_stop | NA (NA, NA) | 34 (14, 52) | 23 (12, 30) | 23 (8, 40) | |
| post_p | NA (NA, NA) | 0.43 (0.04, 0.88) | 0.96 (0.58, 1) | 0.55 (0.11, 0.92) | |
| rate | 0.022 (0.02, 0.023) | 0.023 (0.02, 0.026) | 0.019 (0.016, 0.022) | 0.022 (0.02, 0.025) | |
| DRD+ | graduation | 0 | 3 | 350 | 7 |
| futility | 0 | 76 | 1 | 60 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 200 (164, 229) | 74 (38, 126) | 112 (62, 174) | 74 (34, 127) | |
| n_unique | 200 (164, 229) | 74 (38, 126) | 112 (62, 174) | 74 (34, 127) | |
| time_trial | 60 (60, 60) | 60 (46, 60) | 42 (21, 60) | 60 (50, 60) | |
| time_stop | NA (NA, NA) | 43 (34, 56) | 34 (20, 53) | 45 (35, 57) | |
| post_p | NA (NA, NA) | 0.53 (0.1, 0.91) | 1 (1, 1) | 0.56 (0.13, 0.95) | |
| rate | 0.021 (0.018, 0.023) | 0.02 (0.015, 0.026) | 0.01 (0.008, 0.012) | 0.019 (0.014, 0.026) | |
| TEfus+ | graduation | 0 | 31 | 4 | 33 |
| futility | 0 | 59 | 44 | 67 | |
| max_n | 0 | 0 | 0 | 1 | |
| n | 269 (234, 295) | 126 (57, 195) | 103 (57, 166) | 134 (59, 208) | |
| n_unique | 269 (234, 295) | 126 (57, 195) | 103 (57, 166) | 134 (59, 208) | |
| time_trial | 60 (60, 60) | 60 (36, 60) | 60 (60, 60) | 60 (34, 60) | |
| time_stop | NA (NA, NA) | 35 (23, 55) | 30 (22, 43) | 34 (22, 51) | |
| post_p | NA (NA, NA) | 0.67 (0.16, 0.97) | 0.62 (0.12, 0.96) | 0.76 (0.23, 0.98) | |
| rate | 0.017 (0.015, 0.019) | 0.016 (0.013, 0.02) | 0.017 (0.013, 0.021) | 0.015 (0.013, 0.02) | |
| TP53- | graduation | 0 | 28 | 22 | 31 |
| futility | 0 | 125 | 20 | 101 | |
| max_n | 0 | 69 | 52 | 77 | |
| n | 403 (357, 445) | 187 (72, 302) | 191 (90, 300) | 178 (67, 302) | |
| n_unique | 403 (357, 445) | 187 (72, 302) | 191 (90, 300) | 178 (67, 302) | |
| time_trial | 60 (60, 60) | 60 (24, 60) | 60 (60, 60) | 60 (24, 60) | |
| time_stop | NA (NA, NA) | 30 (18, 52) | 22 (15, 35) | 28 (17, 51) | |
| post_p | NA (NA, NA) | 0.52 (0.07, 0.93) | 0.85 (0.33, 1) | 0.69 (0.16, 0.98) | |
| rate | 0.021 (0.019, 0.023) | 0.021 (0.018, 0.026) | 0.019 (0.015, 0.022) | 0.02 (0.016, 0.025) | |
| TP53+ | graduation | 0 | 12 | 46 | 20 |
| futility | 0 | 211 | 7 | 190 | |
| max_n | 0 | 7 | 13 | 14 | |
| n | 332 (300, 365) | 135 (54, 240) | 164 (83, 255) | 151 (54, 260) | |
| n_unique | 332 (300, 365) | 135 (54, 240) | 164 (83, 255) | 151 (54, 260) | |
| time_trial | 60 (60, 60) | 60 (26, 60) | 60 (49, 60) | 60 (22, 60) | |
| time_stop | NA (NA, NA) | 35 (22, 54) | 28 (18, 46) | 31 (17, 52) | |
| post_p | NA (NA, NA) | 0.34 (0.05, 0.81) | 0.94 (0.53, 1) | 0.36 (0.05, 0.83) | |
| rate | 0.023 (0.021, 0.025) | 0.025 (0.021, 0.03) | 0.019 (0.016, 0.022) | 0.025 (0.021, 0.031) |
| subtype | var | Control | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|
| — | graduation | 0 | 161 | 50 | 154 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 69 | 52 | 77 | |
| n | 225 (187, 255) | 88 (33, 201) | 106 (30, 201) | 77 (24, 188) | |
| n_unique | 225 (187, 255) | 88 (33, 201) | 106 (30, 201) | 77 (24, 188) | |
| post_p | NA (NA, NA) | 0.32 (0.04, 0.8) | 0.32 (0.05, 0.8) | 0.29 (0.06, 0.78) | |
| rate | 0.025 (0.022, 0.028) | 0.028 (0.023, 0.036) | 0.027 (0.022, 0.035) | 0.028 (0.023, 0.038) | |
| –+ | graduation | 0 | 204 | 84 | 199 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 68 | 52 | 78 | |
| n | 65 (52, 79) | 35 (9, 64) | 12 (5, 34) | 41 (12, 69) | |
| n_unique | 65 (52, 79) | 35 (9, 64) | 12 (5, 34) | 41 (12, 69) | |
| post_p | NA (NA, NA) | 0.69 (0.28, 0.96) | 0.08 (0.01, 0.27) | 0.74 (0.35, 0.97) | |
| rate | 0.013 (0.01, 0.017) | 0.011 (0.007, 0.018) | 0.029 (0.02, 0.051) | 0.011 (0.007, 0.017) | |
| -+- | graduation | 0 | 236 | 66 | 233 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 7 | 13 | 14 | |
| n | 144 (120, 165) | 50 (15, 124) | 70 (17, 133) | 51 (19, 132) | |
| n_unique | 144 (120, 165) | 50 (15, 124) | 70 (17, 133) | 51 (19, 132) | |
| post_p | NA (NA, NA) | 0.32 (0.06, 0.8) | 0.35 (0.07, 0.81) | 0.34 (0.04, 0.78) | |
| rate | 0.024 (0.021, 0.028) | 0.028 (0.022, 0.041) | 0.026 (0.021, 0.036) | 0.028 (0.023, 0.038) | |
| -++ | graduation | 0 | 279 | 105 | 283 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 7 | 12 | 14 | |
| n | 106 (87, 123) | 41 (13, 97) | 30 (11, 86) | 44 (16, 103) | |
| n_unique | 106 (87, 123) | 41 (13, 97) | 30 (11, 86) | 44 (16, 103) | |
| post_p | NA (NA, NA) | 0.45 (0.09, 0.87) | 0.16 (0.02, 0.56) | 0.51 (0.12, 0.9) | |
| rate | 0.021 (0.018, 0.025) | 0.022 (0.017, 0.033) | 0.028 (0.022, 0.04) | 0.022 (0.017, 0.031) | |
| +– | graduation | 0 | 206 | 348 | 201 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 68 | 48 | 77 | |
| n | 59 (44, 72) | 18 (5, 44) | 34 (15, 62) | 16 (4, 43) | |
| n_unique | 59 (44, 72) | 18 (5, 44) | 34 (15, 62) | 16 (4, 43) | |
| post_p | NA (NA, NA) | 0.35 (0.08, 0.78) | 1 (0.94, 1) | 0.34 (0.08, 0.78) | |
| rate | 0.025 (0.02, 0.031) | 0.028 (0.018, 0.049) | 0.01 (0.007, 0.015) | 0.028 (0.019, 0.05) | |
| +-+ | graduation | 0 | 244 | 371 | 240 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 67 | 48 | 78 | |
| n | 55 (38, 70) | 24 (6, 49) | 24 (13, 42) | 23 (6, 49) | |
| n_unique | 55 (38, 70) | 24 (6, 49) | 24 (13, 42) | 23 (6, 49) | |
| post_p | NA (NA, NA) | 0.59 (0.2, 0.9) | 0.77 (0.3, 0.95) | 0.66 (0.29, 0.94) | |
| rate | 0.013 (0.01, 0.018) | 0.011 (0.007, 0.021) | 0.01 (0.006, 0.016) | 0.01 (0.005, 0.019) | |
| ++- | graduation | 0 | 273 | 367 | 265 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 7 | 12 | 14 | |
| n | 43 (30, 55) | 11 (4, 32) | 25 (12, 46) | 13 (3, 34) | |
| n_unique | 43 (30, 55) | 11 (4, 32) | 25 (12, 46) | 13 (3, 34) | |
| post_p | NA (NA, NA) | 0.36 (0.09, 0.76) | 0.99 (0.9, 1) | 0.38 (0.11, 0.77) | |
| rate | 0.025 (0.019, 0.032) | 0.029 (0.018, 0.05) | 0.01 (0.006, 0.015) | 0.028 (0.017, 0.053) | |
| +++ | graduation | 0 | 308 | 394 | 312 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 7 | 11 | 14 | |
| n | 43 (28, 54) | 14 (4, 34) | 21 (10, 44) | 11 (3, 33) | |
| n_unique | 43 (28, 54) | 14 (4, 34) | 21 (10, 44) | 11 (3, 33) | |
| post_p | NA (NA, NA) | 0.44 (0.11, 0.81) | 0.96 (0.7, 1) | 0.42 (0.12, 0.82) | |
| rate | 0.021 (0.016, 0.028) | 0.022 (0.013, 0.041) | 0.01 (0.006, 0.016) | 0.022 (0.013, 0.045) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|
| all | count | 5 | 10 | 14 |
| time_stop | 17 (16, 36) | 22 (17, 27) | 24 (11, 31) | |
| n_trt | 109 (98, 174) | 140 (111, 188) | 146 (64, 233) | |
| n_control | 187 (173, 407) | 238 (184, 305) | 260 (129, 359) | |
| post_p | 0.98 (0.97, 0.99) | 0.94 (0.9, 0.99) | 1 (0.95, 1) | |
| order | 1 (1, 3.4) | 1 (1, 3.1) | 1.5 (1, 2) | |
| TP53- | count | 28 | 31 | 22 |
| time_stop | 30 (19, 55) | 31 (19, 57) | 24 (16, 39) | |
| n_trt | 118 (68, 247) | 147 (73, 272) | 89 (58, 135) | |
| n_control | 172 (112, 353) | 207 (113, 359) | 135 (94, 239) | |
| post_p | 0.94 (0.89, 0.98) | 0.97 (0.9, 0.99) | 0.99 (0.96, 1) | |
| order | 1 (1, 2) | 1 (1, 3) | 2 (1, 3) | |
| TP53+ | count | 12 | 20 | 46 |
| time_stop | 28 (19, 47) | 27 (20, 55) | 28 (18, 46) | |
| n_trt | 79 (54, 145) | 94 (59, 185) | 92 (54, 150) | |
| n_control | 128 (91, 230) | 134 (79, 298) | 154 (85, 234) | |
| post_p | 0.95 (0.87, 0.99) | 0.95 (0.89, 0.98) | 0.99 (0.97, 1) | |
| order | 1 (1, 2) | 2 (1, 3.1) | 1 (1, 2.5) | |
| DRD+ | count | 3 | 7 | 350 |
| time_stop | 36 (32, 51) | 46 (35, 58) | 34 (20, 53) | |
| n_trt | 81 (59, 115) | 76 (51, 104) | 94 (58, 151) | |
| n_control | 130 (108, 146) | 170 (112, 198) | 107 (64, 172) | |
| post_p | 0.99 (0.98, 0.99) | 1 (0.96, 1) | 1 (0.97, 1) | |
| order | 2 (1.2, 2) | 2 (1, 2.8) | 1 (1, 2) | |
| TEfus+ | count | 31 | 33 | 4 |
| time_stop | 43 (23, 57) | 39 (20, 51) | 30 (18, 46) | |
| n_trt | 104 (56, 175) | 103 (54, 174) | 74 (57, 105) | |
| n_control | 183 (93, 246) | 157 (83, 230) | 118 (77, 199) | |
| post_p | 0.97 (0.91, 1) | 0.96 (0.89, 0.99) | 0.95 (0.9, 0.98) | |
| order | 2 (1, 3) | 2 (1, 3) | 3 (2.3, 3) |
| signature | var | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|
| all | count | 33 | 39 | 2 |
| time_stop | 35 (13, 55) | 23 (8, 42) | 15 (14, 16) | |
| n_trt | 161 (67, 273) | 107 (55, 202) | 83 (82, 84) | |
| n_control | 415 (153, 718) | 268 (89, 480) | 158 (148, 167) | |
| post_p | 0.03 (0.01, 0.17) | 0.06 (0.01, 0.21) | 0.22 (0.2, 0.24) | |
| order | 3 (1, 4.8) | 2 (1, 4) | 1 (1, 1) | |
| TP53- | count | 125 | 101 | 20 |
| time_stop | 30 (17, 51) | 27 (16, 47) | 20 (15, 27) | |
| n_trt | 92 (53, 205) | 86 (54, 168) | 71 (54, 93) | |
| n_control | 183 (104, 337) | 175 (95, 319) | 114 (88, 170) | |
| post_p | 0.11 (0.03, 0.24) | 0.16 (0.05, 0.28) | 0.2 (0.09, 0.27) | |
| order | 1 (1, 3) | 2 (1, 3) | 1 (1, 2) | |
| TP53+ | count | 211 | 190 | 7 |
| time_stop | 35 (22, 54) | 32 (17, 51) | 25 (21, 35) | |
| n_trt | 79 (52, 160) | 83 (51, 159) | 55 (52, 101) | |
| n_control | 188 (110, 302) | 170 (84, 286) | 145 (104, 207) | |
| post_p | 0.13 (0.03, 0.26) | 0.13 (0.03, 0.25) | 0.28 (0.19, 0.3) | |
| order | 2 (1, 4) | 1 (1, 3) | 2 (1, 3.4) | |
| DRD+ | count | 76 | 60 | 1 |
| time_stop | 43 (34, 56) | 45 (35, 53) | 16 (16, 16) | |
| n_trt | 60 (50, 100) | 62 (51, 89) | 52 (52, 52) | |
| n_control | 148 (111, 194) | 144 (115, 190) | 55 (55, 55) | |
| post_p | 0.16 (0.04, 0.27) | 0.16 (0.07, 0.26) | 0.29 (0.29, 0.29) | |
| order | 2 (1, 5) | 2 (1, 4) | 2 (2, 2) | |
| TEfus+ | count | 59 | 67 | 44 |
| time_stop | 34 (25, 54) | 33 (23, 49) | 30 (22, 43) | |
| n_trt | 67 (51, 122) | 72 (52, 112) | 65 (51, 106) | |
| n_control | 146 (101, 247) | 141 (92, 227) | 129 (87, 199) | |
| post_p | 0.18 (0.02, 0.25) | 0.12 (0.04, 0.23) | 0.12 (0.04, 0.25) | |
| order | 2 (1, 5) | 2 (1, 4) | 2 (1, 4) |
| signature | treatment | var | — | –+ | -+- | -++ | +– | +-+ | ++- | +++ |
|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| time | 17 (16, 36) | 17 (16, 36) | 17 (16, 36) | 17 (16, 36) | 17 (16, 36) | 17 (16, 36) | 17 (16, 36) | 17 (16, 36) | ||
| n | 44 (24, 51) | 9 (4, 12) | 26 (14, 35) | 15 (15, 43) | 7 (5, 8) | 5 (3, 7) | 4 (2, 19) | 5 (3, 19) | ||
| post_p | 0.81 (0.61, 0.9) | 0.59 (0.58, 0.74) | 0.74 (0.57, 0.89) | 0.83 (0.71, 0.92) | 0.66 (0.59, 0.67) | 0.58 (0.56, 0.76) | 0.56 (0.56, 0.64) | 0.62 (0.59, 0.68) | ||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.018 (0.014, 0.028) | 0 (0, 0.004) | 0.015 (0.002, 0.021) | 0.01 (0.001, 0.017) | 0 (0, 0.015) | 0 (0, 0) | 0 (0, 0.014) | 0 (0, 0.022) | ||
| Niraparib | count | 14 | 14 | 14 | 14 | 14 | 14 | 14 | 14 | |
| time | 24 (11, 31) | 24 (11, 31) | 24 (11, 31) | 24 (11, 31) | 24 (11, 31) | 24 (11, 31) | 24 (11, 31) | 24 (11, 31) | ||
| n | 30 (10, 71) | 6 (4, 14) | 18 (7, 43) | 20 (7, 37) | 13 (6, 24) | 16 (11, 24) | 12 (6, 25) | 12 (6, 20) | ||
| post_p | 0.65 (0.6, 0.84) | 0.58 (0.56, 0.62) | 0.64 (0.6, 0.82) | 0.59 (0.56, 0.65) | 0.73 (0.64, 0.96) | 0.74 (0.57, 0.92) | 0.81 (0.63, 0.98) | 0.72 (0.61, 0.86) | ||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||
| rate | 0.017 (0, 0.02) | 0.006 (0, 0.013) | 0.013 (0, 0.026) | 0.012 (0, 0.019) | 0.002 (0, 0.016) | 0 (0, 0.01) | 0.002 (0, 0.009) | 0 (0, 0.011) | ||
| Taxel_therapies | count | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | |
| time | 22 (17, 27) | 22 (17, 27) | 22 (17, 27) | 22 (17, 27) | 22 (17, 27) | 22 (17, 27) | 22 (17, 27) | 22 (17, 27) | ||
| n | 46 (25, 58) | 16 (13, 27) | 24 (17, 55) | 25 (17, 49) | 11 (2, 17) | 8 (4, 14) | 9 (5, 11) | 5 (0, 7) | ||
| post_p | 0.72 (0.63, 0.85) | 0.7 (0.56, 0.82) | 0.61 (0.6, 0.72) | 0.82 (0.61, 0.92) | 0.62 (0.57, 0.83) | 0.61 (0.56, 0.68) | 0.65 (0.57, 0.72) | 0.64 (0.58, 0.72) | ||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.019 (0.011, 0.022) | 0.005 (0, 0.013) | 0.018 (0.012, 0.024) | 0.013 (0.003, 0.018) | 0 (0, 0.02) | 0 (0, 0.001) | 0 (0, 0.014) | 0 (0, 0.015) | ||
| DRD+ | Hormone_therapies | count | 3 | 3 | 3 | 3 | ||||
| time | 36 (32, 51) | 36 (32, 51) | 36 (32, 51) | 36 (32, 51) | ||||||
| n | 18 (12, 45) | 29 (27, 49) | 10 (7, 18) | 10 (8, 13) | ||||||
| post_p | 0.82 (0.73, 0.85) | 0.82 (0.76, 0.92) | 0.84 (0.68, 0.92) | 0.7 (0.68, 0.71) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.006 (0.005, 0.019) | 0.009 (0.002, 0.009) | 0.009 (0.002, 0.017) | 0.009 (0.007, 0.017) | ||||||
| Niraparib | count | 350 | 350 | 350 | 350 | |||||
| time | 34 (20, 53) | 34 (20, 53) | 34 (20, 53) | 34 (20, 53) | ||||||
| n | 29 (15, 51) | 24 (15, 41) | 21 (11, 38) | 20 (10, 38) | ||||||
| post_p | 0.92 (0.75, 1) | 0.75 (0.7, 0.91) | 0.87 (0.72, 0.99) | 0.82 (0.7, 0.97) | ||||||
| r_prob | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.008 (0, 0.013) | 0.006 (0, 0.011) | 0.007 (0, 0.014) | 0.007 (0, 0.013) | ||||||
| Taxel_therapies | count | 7 | 7 | 7 | 7 | |||||
| time | 46 (35, 58) | 46 (35, 58) | 46 (35, 58) | 46 (35, 58) | ||||||
| n | 17 (9, 30) | 34 (14, 53) | 10 (7, 20) | 14 (11, 18) | ||||||
| post_p | 0.71 (0.67, 0.78) | 0.84 (0.71, 0.92) | 0.7 (0.65, 0.93) | 0.81 (0.78, 0.91) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.019 (0.011, 0.024) | 0.004 (0, 0.007) | 0.016 (0.007, 0.023) | 0.01 (0.003, 0.018) | ||||||
| TEfus+ | Hormone_therapies | count | 31 | 31 | 31 | 31 | ||||
| time | 43 (23, 57) | 43 (23, 57) | 43 (23, 57) | 43 (23, 57) | ||||||
| n | 23 (12, 59) | 35 (16, 75) | 15 (6, 33) | 14 (5, 31) | ||||||
| post_p | 0.78 (0.71, 0.91) | 0.8 (0.71, 0.94) | 0.73 (0.65, 0.86) | 0.72 (0.63, 0.86) | ||||||
| r_prob | 0.19 (0.19, 0.19) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.006 (0, 0.011) | 0.014 (0.007, 0.019) | 0.002 (0, 0.009) | 0.011 (0, 0.018) | ||||||
| Niraparib | count | 4 | 4 | 4 | 4 | |||||
| time | 30 (18, 46) | 30 (18, 46) | 30 (18, 46) | 30 (18, 46) | ||||||
| n | 9 (8, 9) | 31 (18, 66) | 15 (13, 17) | 18 (14, 19) | ||||||
| post_p | 0.61 (0.6, 0.64) | 0.77 (0.74, 0.83) | 0.8 (0.73, 0.93) | 0.85 (0.76, 0.94) | ||||||
| r_prob | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.005 (0, 0.013) | 0.013 (0.003, 0.016) | 0.001 (0, 0.004) | 0.009 (0.005, 0.012) | ||||||
| Taxel_therapies | count | 33 | 33 | 33 | 33 | |||||
| time | 39 (20, 51) | 39 (20, 51) | 39 (20, 51) | 39 (20, 51) | ||||||
| n | 28 (14, 49) | 48 (26, 88) | 14 (6, 35) | 9 (5, 29) | ||||||
| post_p | 0.79 (0.71, 0.93) | 0.81 (0.71, 0.97) | 0.75 (0.64, 0.89) | 0.72 (0.62, 0.89) | ||||||
| r_prob | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.006 (0, 0.01) | 0.014 (0.008, 0.021) | 0.003 (0, 0.006) | 0.009 (0, 0.016) | ||||||
| TP53- | Hormone_therapies | count | 28 | 28 | 28 | 28 | ||||
| time | 30 (19, 55) | 30 (19, 55) | 30 (19, 55) | 30 (19, 55) | ||||||
| n | 76 (37, 155) | 22 (10, 44) | 12 (6, 27) | 12 (5, 34) | ||||||
| post_p | 0.79 (0.71, 0.94) | 0.76 (0.71, 0.92) | 0.73 (0.62, 0.9) | 0.71 (0.6, 0.89) | ||||||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.02 (0.015, 0.024) | 0.007 (0, 0.01) | 0.008 (0, 0.019) | 0 (0, 0.008) | ||||||
| Niraparib | count | 22 | 22 | 22 | 22 | |||||
| time | 24 (16, 39) | 24 (16, 39) | 24 (16, 39) | 24 (16, 39) | ||||||
| n | 44 (20, 83) | 8 (5, 19) | 18 (9, 26) | 18 (13, 25) | ||||||
| post_p | 0.79 (0.74, 0.87) | 0.65 (0.62, 0.77) | 0.9 (0.71, 0.98) | 0.75 (0.71, 0.94) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.014 (0, 0.022) | 0 (0, 0.01) | 0.005 (0, 0.012) | 0.004 (0, 0.012) | ||||||
| Taxel_therapies | count | 31 | 31 | 31 | 31 | |||||
| time | 31 (19, 57) | 31 (19, 57) | 31 (19, 57) | 31 (19, 57) | ||||||
| n | 69 (42, 144) | 26 (16, 58) | 10 (3, 36) | 13 (6, 43) | ||||||
| post_p | 0.79 (0.7, 0.94) | 0.79 (0.71, 0.92) | 0.72 (0.62, 0.85) | 0.76 (0.62, 0.87) | ||||||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.019 (0.011, 0.023) | 0.007 (0, 0.012) | 0.012 (0, 0.021) | 0 (0, 0.009) | ||||||
| TP53+ | Hormone_therapies | count | 12 | 12 | 12 | 12 | ||||
| time | 28 (19, 47) | 28 (19, 47) | 28 (19, 47) | 28 (19, 47) | ||||||
| n | 44 (23, 68) | 25 (9, 37) | 8 (5, 10) | 8 (3, 18) | ||||||
| post_p | 0.79 (0.72, 0.94) | 0.73 (0.67, 0.93) | 0.67 (0.62, 0.82) | 0.66 (0.61, 0.76) | ||||||
| r_prob | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.016 (0.01, 0.021) | 0.01 (0.004, 0.019) | 0 (0, 0.019) | 0 (0, 0.015) | ||||||
| Niraparib | count | 46 | 46 | 46 | 46 | |||||
| time | 28 (18, 46) | 28 (18, 46) | 28 (18, 46) | 28 (18, 46) | ||||||
| n | 36 (12, 70) | 21 (11, 40) | 16 (10, 30) | 14 (8, 30) | ||||||
| post_p | 0.76 (0.71, 0.91) | 0.76 (0.7, 0.87) | 0.85 (0.71, 0.97) | 0.85 (0.66, 0.99) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.014 (0.003, 0.022) | 0.01 (0, 0.02) | 0.007 (0, 0.013) | 0.007 (0, 0.016) | ||||||
| Taxel_therapies | count | 20 | 20 | 20 | 20 | |||||
| time | 27 (20, 55) | 27 (20, 55) | 27 (20, 55) | 27 (20, 55) | ||||||
| n | 47 (20, 85) | 31 (22, 68) | 9 (4, 29) | 7 (4, 19) | ||||||
| post_p | 0.77 (0.73, 0.92) | 0.83 (0.71, 0.9) | 0.7 (0.62, 0.87) | 0.69 (0.6, 0.76) | ||||||
| r_prob | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.018 (0.013, 0.024) | 0.012 (0.009, 0.02) | 0.008 (0, 0.015) | 0 (0, 0.015) |
| signature | treatment | var | — | –+ | -+- | -++ | +– | +-+ | ++- | +++ |
|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 33 | 33 | 33 | 33 | 33 | 33 | 33 | 33 |
| time | 35 (13, 55) | 35 (13, 55) | 35 (13, 55) | 35 (13, 55) | 35 (13, 55) | 35 (13, 55) | 35 (13, 55) | 35 (13, 55) | ||
| n | 49 (27, 157) | 12 (5, 34) | 20 (6, 54) | 19 (7, 55) | 8 (2, 25) | 10 (2, 25) | 6 (2, 17) | 6 (2, 19) | ||
| post_p | 0.24 (0.06, 0.42) | 0.38 (0.23, 0.48) | 0.26 (0.07, 0.45) | 0.39 (0.17, 0.48) | 0.32 (0.14, 0.47) | 0.37 (0.15, 0.49) | 0.38 (0.13, 0.48) | 0.38 (0.24, 0.47) | ||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.028 (0.023, 0.034) | 0.017 (0.01, 0.032) | 0.031 (0.023, 0.047) | 0.022 (0.017, 0.041) | 0.028 (0.013, 0.065) | 0.016 (0.009, 0.036) | 0.031 (0.018, 0.043) | 0.026 (0.011, 0.088) | ||
| Niraparib | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |
| time | 15 (14, 16) | 15 (14, 16) | 15 (14, 16) | 15 (14, 16) | 15 (14, 16) | 15 (14, 16) | 15 (14, 16) | 15 (14, 16) | ||
| n | 9 (4, 14) | 5 (3, 7) | 8 (7, 8) | 13 (8, 18) | 13 (13, 13) | 14 (13, 14) | 12 (12, 12) | 10 (8, 12) | ||
| post_p | 0.41 (0.38, 0.44) | 0.3 (0.17, 0.43) | 0.41 (0.39, 0.43) | 0.34 (0.29, 0.4) | 0.39 (0.33, 0.44) | 0.27 (0.25, 0.3) | 0.43 (0.41, 0.46) | 0.46 (0.43, 0.49) | ||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||
| rate | 0.035 (0.025, 0.044) | 0.043 (0.009, 0.078) | 0.025 (0.025, 0.025) | 0.034 (0.03, 0.038) | 0.019 (0.012, 0.025) | 0.016 (0.015, 0.018) | 0.012 (0.009, 0.015) | 0.015 (0.015, 0.016) | ||
| Taxel_therapies | count | 39 | 39 | 39 | 39 | 39 | 39 | 39 | 39 | |
| time | 23 (8, 42) | 23 (8, 42) | 23 (8, 42) | 23 (8, 42) | 23 (8, 42) | 23 (8, 42) | 23 (8, 42) | 23 (8, 42) | ||
| n | 30 (16, 74) | 12 (6, 24) | 19 (12, 56) | 19 (10, 33) | 5 (0, 13) | 4 (0, 14) | 3 (1, 10) | 2 (1, 11) | ||
| post_p | 0.27 (0.15, 0.48) | 0.43 (0.34, 0.49) | 0.3 (0.08, 0.46) | 0.4 (0.16, 0.46) | 0.39 (0.14, 0.49) | 0.38 (0.22, 0.48) | 0.32 (0.12, 0.49) | 0.4 (0.17, 0.49) | ||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.027 (0.02, 0.041) | 0.017 (0, 0.025) | 0.027 (0.018, 0.039) | 0.021 (0.014, 0.037) | 0.026 (0, 0.076) | 0.013 (0, 0.025) | 0.035 (0, 0.152) | 0.021 (0, 0.059) | ||
| DRD+ | Hormone_therapies | count | 76 | 76 | 76 | 76 | ||||
| time | 43 (34, 56) | 43 (34, 56) | 43 (34, 56) | 43 (34, 56) | ||||||
| n | 20 (8, 38) | 18 (6, 34) | 10 (3, 24) | 13 (5, 28) | ||||||
| post_p | 0.3 (0.09, 0.46) | 0.39 (0.19, 0.48) | 0.32 (0.09, 0.46) | 0.3 (0.13, 0.48) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.027 (0.02, 0.043) | 0.014 (0.01, 0.023) | 0.032 (0.023, 0.049) | 0.024 (0.017, 0.04) | ||||||
| Niraparib | count | 1 | 1 | 1 | 1 | |||||
| time | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | ||||||
| n | 13 (13, 13) | 14 (14, 14) | 12 (12, 12) | 13 (13, 13) | ||||||
| post_p | 0.46 (0.46, 0.46) | 0.24 (0.24, 0.24) | 0.46 (0.46, 0.46) | 0.5 (0.5, 0.5) | ||||||
| r_prob | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.027 (0.027, 0.027) | 0.014 (0.014, 0.014) | 0.016 (0.016, 0.016) | 0.015 (0.015, 0.015) | ||||||
| Taxel_therapies | count | 60 | 60 | 60 | 60 | |||||
| time | 45 (35, 53) | 45 (35, 53) | 45 (35, 53) | 45 (35, 53) | ||||||
| n | 16 (6, 31) | 18 (9, 36) | 15 (6, 29) | 10 (3, 25) | ||||||
| post_p | 0.3 (0.1, 0.45) | 0.38 (0.23, 0.48) | 0.36 (0.11, 0.47) | 0.3 (0.09, 0.46) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.031 (0.021, 0.049) | 0.013 (0.009, 0.021) | 0.028 (0.019, 0.048) | 0.025 (0.018, 0.054) | ||||||
| TEfus+ | Hormone_therapies | count | 59 | 59 | 59 | 59 | ||||
| time | 34 (25, 54) | 34 (25, 54) | 34 (25, 54) | 34 (25, 54) | ||||||
| n | 16 (6, 35) | 26 (14, 64) | 13 (5, 25) | 8 (4, 19) | ||||||
| post_p | 0.39 (0.19, 0.48) | 0.29 (0.14, 0.47) | 0.37 (0.16, 0.49) | 0.34 (0.17, 0.46) | ||||||
| r_prob | 0.19 (0.19, 0.19) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.014 (0.01, 0.026) | 0.023 (0.017, 0.034) | 0.015 (0.009, 0.028) | 0.027 (0.016, 0.039) | ||||||
| Niraparib | count | 44 | 44 | 44 | 44 | |||||
| time | 30 (22, 43) | 30 (22, 43) | 30 (22, 43) | 30 (22, 43) | ||||||
| n | 9 (4, 18) | 26 (14, 46) | 18 (11, 30) | 13 (7, 23) | ||||||
| post_p | 0.24 (0.05, 0.42) | 0.28 (0.09, 0.46) | 0.35 (0.2, 0.48) | 0.41 (0.24, 0.49) | ||||||
| r_prob | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.028 (0.015, 0.069) | 0.025 (0.018, 0.031) | 0.014 (0.009, 0.025) | 0.018 (0.012, 0.027) | ||||||
| Taxel_therapies | count | 67 | 67 | 67 | 67 | |||||
| time | 33 (23, 49) | 33 (23, 49) | 33 (23, 49) | 33 (23, 49) | ||||||
| n | 21 (11, 40) | 29 (18, 54) | 11 (5, 29) | 8 (2, 19) | ||||||
| post_p | 0.4 (0.22, 0.48) | 0.31 (0.12, 0.49) | 0.36 (0.19, 0.48) | 0.33 (0.13, 0.48) | ||||||
| r_prob | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.015 (0.01, 0.024) | 0.022 (0.016, 0.032) | 0.014 (0.009, 0.034) | 0.029 (0.014, 0.078) | ||||||
| TP53- | Hormone_therapies | count | 125 | 125 | 125 | 125 | ||||
| time | 30 (17, 51) | 30 (17, 51) | 30 (17, 51) | 30 (17, 51) | ||||||
| n | 52 (29, 130) | 16 (5, 35) | 11 (4, 29) | 9 (3, 25) | ||||||
| post_p | 0.29 (0.08, 0.48) | 0.4 (0.22, 0.48) | 0.36 (0.13, 0.47) | 0.38 (0.15, 0.49) | ||||||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.026 (0.02, 0.033) | 0.015 (0.009, 0.029) | 0.028 (0.016, 0.058) | 0.015 (0, 0.033) | ||||||
| Niraparib | count | 20 | 20 | 20 | 20 | |||||
| time | 20 (15, 27) | 20 (15, 27) | 20 (15, 27) | 20 (15, 27) | ||||||
| n | 32 (24, 55) | 6 (4, 9) | 14 (8, 22) | 15 (11, 23) | ||||||
| post_p | 0.34 (0.16, 0.49) | 0.24 (0.14, 0.4) | 0.44 (0.32, 0.48) | 0.41 (0.31, 0.48) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.021 (0.014, 0.031) | 0.035 (0.016, 0.064) | 0.017 (0.009, 0.029) | 0.011 (0.007, 0.022) | ||||||
| Taxel_therapies | count | 101 | 101 | 101 | 101 | |||||
| time | 27 (16, 47) | 27 (16, 47) | 27 (16, 47) | 27 (16, 47) | ||||||
| n | 46 (24, 105) | 18 (8, 41) | 7 (3, 21) | 10 (4, 21) | ||||||
| post_p | 0.34 (0.06, 0.46) | 0.41 (0.2, 0.48) | 0.34 (0.15, 0.48) | 0.35 (0.2, 0.47) | ||||||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.026 (0.02, 0.036) | 0.014 (0.009, 0.024) | 0.027 (0.016, 0.078) | 0.016 (0.007, 0.041) | ||||||
| TP53+ | Hormone_therapies | count | 211 | 211 | 211 | 211 | ||||
| time | 35 (22, 54) | 35 (22, 54) | 35 (22, 54) | 35 (22, 54) | ||||||
| n | 32 (11, 87) | 24 (11, 56) | 8 (3, 20) | 9 (4, 26) | ||||||
| post_p | 0.3 (0.08, 0.48) | 0.32 (0.12, 0.48) | 0.35 (0.13, 0.47) | 0.35 (0.12, 0.48) | ||||||
| r_prob | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.027 (0.02, 0.043) | 0.024 (0.017, 0.037) | 0.028 (0.018, 0.073) | 0.024 (0.015, 0.05) | ||||||
| Niraparib | count | 7 | 7 | 7 | 7 | |||||
| time | 25 (21, 35) | 25 (21, 35) | 25 (21, 35) | 25 (21, 35) | ||||||
| n | 19 (14, 56) | 15 (5, 29) | 10 (4, 12) | 13 (11, 18) | ||||||
| post_p | 0.42 (0.3, 0.48) | 0.24 (0.15, 0.38) | 0.45 (0.43, 0.48) | 0.3 (0.2, 0.49) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.026 (0.022, 0.028) | 0.037 (0.024, 0.066) | 0.016 (0.014, 0.027) | 0.018 (0.013, 0.031) | ||||||
| Taxel_therapies | count | 190 | 190 | 190 | 190 | |||||
| time | 32 (17, 51) | 32 (17, 51) | 32 (17, 51) | 32 (17, 51) | ||||||
| n | 35 (19, 84) | 28 (15, 60) | 7 (3, 24) | 7 (2, 20) | ||||||
| post_p | 0.28 (0.06, 0.46) | 0.37 (0.14, 0.48) | 0.34 (0.12, 0.48) | 0.36 (0.18, 0.48) | ||||||
| r_prob | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.027 (0.02, 0.036) | 0.023 (0.016, 0.031) | 0.031 (0.017, 0.084) | 0.027 (0.014, 0.075) |